Etidronic Acid in Cosmetics, Etidronate for Osteoporosis

Etidronic Acid in Cosmetics


Because etidronic acid has a good chelating ability. trapping heavy metal ions from a cosmetic preparation. By complexing heavy metal ions, the sequestrant stabilizes the cosmetic by stabilizing the oxidation compounds. That extends its durability. The etidronic acid also exists in shampoo and soap.

Etidronic Acid Side Effects in Cosmetics and Soap

There are few warnings about the etidronic acid side effects on skin care cosmetics or soap. It is important to note that although etidronic acid is not restricted in cosmetics, it does have legitimate USES. It is still recommended that like most cosmetics (especially soap), they should be cleaned thoroughly after used by people.

Etidronic acid is a kind of organic phosphoric acid. If it is not thoroughly cleaned, the residual chemicals may be corrosive to the skin. If inhaled, it burns skin and mucous membranes. If they are exposed to the eye, they may cause burns to the cornea.

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Safety Assessment of Etidronic Acid and Its Simple Salts as Used in Cosmetics
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Etidronate for Osteoporosis

As a bisphosphonate, etidronate is effective in reducing bone loss and reducing fracture rate. It is widely used in postmenopausal osteoporosis, deformed osteitis and hypercalcemia. This product is a bone metabolism regulating the drug. It has a strong affinity for calcium phosphate in the body, which can restrain abnormal calcification and excessive bone absorption and alleviate bone pain.


Etidronate also can reduce serum alkaline phosphatase and hydroxyproline concentration. In low doses, this kind of etidronic acid salt can directly inhibit osteoclasts. The bone resorption also can be prevented. and bone density and bone density can be increased. By reducing the bone turnover rate and increasing bone density, etidronate can adjust bone calcium.

Etidronate Side Effects in Medicine

There are several common adverse reactions as below.

  • Gastrointestinal reactions, such as nausea, vomiting and diarrhoea. Bisphosphonates have a low incidence, while high doses of etidronate have a high incidence of 20% to 30%
  • Causing osteomalacia. The first generation of etidronate may cause osteomalacia. But that rarely happens in the second and third generation of etidronate rarely cause osteomalacia
  • Other adverse reactions are mainly renal damage

Doctor’s Advice

For better absorption and avoid etidronate (bisphosphonate) to stimulate the oesophagus and stomach. It is recommended that bisphosphonates should be taken on an empty stomach in the morning (30 minutes before breakfast) with sufficient water to be delivered. And then stand or sit for 30 minutes.

Do not drink milk and milk products, orange juice, coffee, tea, mineral water, fruit juice and calcium-containing drinking before taking the drug which contains the etidronate. Patients with gastritis and duodenal ulcer should be used with caution.

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Etidronic Acid (A Review of its Pharmacological Properties and Therapeutic Efficacy in Resorptive Bone Disease)
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